Welcome!
Dr. Rubul Mout is a scientist (Research Fellow) at Harvard Medical School and Boston Children's Hospital, working in protein design, hematopoietic stem & T-cell development, and immuno-ageing.
He is also the author of two books in Assamese.
He founded Uplift Libraries, an initiative to create small-scale libraries for children in rural India. Currently, it has six libraries and serves underprivileged students.
Every Sunday, he runs an outreach program through Zoom (Sunday Science Activism) to interact with college and university students from around the world.
His journey in science and writing has been featured in this Apple podcast.
Full Biography:
Dr. Rubul Mout is a Fellow (Research) at Harvard Medical School, Harvard University, and the Stem Cell & Regenerative Biology Program, Boston Children’s Hospital (BCH).
Born, brought up, and educated in India, Dr. Mout moved to the United States to pursue his PhD from the University of Massachusetts, Amherst. Prior to joining Harvard/BCH, he was a Washington Research Foundation Innovation Fellow at the Institute for Protein Design, University of Washington.
At Harvard/BCH, Dr. Mout developed soluble agonists for the Notch signaling pathway for T cell development and function (Mout et al., Cell, 2025). These agonists promoted the development of T cells from bone marrow stem cells (also called Hematopoietic stem cells, or HSCs) and activated the Notch pathway in T cells during vaccination to boost cell-based immunity. Currently, Dr. Mout uses computational protein design technologies to modulate signaling in immune development, function, and ageing. The ultimate goal of this research is to enhance T cell function to better combat cancer, autoimmune diseases, and viral infections.
Dr. Mout is the co-author of 40 research articles and the inventor of numerous technologies in gene editing, protein design, and T-cell engineering with multiple patents. During his PhD, he developed a technology for intracellular protein delivery and gene editing in mammalian cells, known as the ‘E-tag’ method, which was published in a series of multiple research papers and an approved patent. His work on protein design and Notch signaling in collaboration with his former postdoctoral mentor David Baker (2024 Nobel Laureate in Chemistry), George Daley (Dean, Harvard Medical School), and others was featured in Nature magazine. In addition, his research has been featured in numerous media, including a LabTV/NIH minidocumentary and an American Chemical Society (ACS) feature video.
Dr. Mout is also the author of two books—a collection of short stories and a memoir—in his native language, Assamese. His memoir depicts his extraordinary journey from a poor peasant’s family in a far-remote corner of India, near the Assam-Arunachal border. The book has been an instant bestseller, and since its first publication in 2017, it has sold over 50,000 copies (as of January 2025), making it one of the highest-selling books in the Assamese language. The book is also included in many school/college/university curricula across Assam.
Please visit the following pages to learn more about Dr. Mout's work: