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Bram Raphael, MD

Biography

Xiao Wang received B.A. degrees in Mathematics and Computer Science with honor from Saint John’s University, MN, in 2012, and M.S. E.E. degree in electrical and compute engineering from Purdue University, West Lafayette, IN, in 2016. In 2017, He received a PhD degree in electrical and computer...

Research

The Hla lab is investigating the biology of the lipid mediator sphingosine 1-phosphate (S1P). We are focused on the role of S1P signaling in embryonic development, normal physiology and disease processes relevant to cancer, vascular and immune systems.

Regulation and Function of S1P Gradients

While most cells produce S1P in the intracellular environment as a terminal product of sphingolipid metabolism, vertebrates secrete S1P into the extracellular environment by specific transporters (Proia RL, Hla T. Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy. J...

Resources

Researchers in the Hla lab develop protocols utilizing cutting edge technology combined with classical techniques and model systems to explore the fundamental biology of the vascular system and the diseases that affect it. Click title to open PDF:

Central Venous Catheter Complications, Prevention & Treatment

Outpatient central line infection prevention bundle Encouraging good hand hygiene. Scrubbing the central line hub for 15 seconds before each line access. Changing central line dressing once per week or more frequently if soiled, using aseptic technique. Change the central line end cap using clean...