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Microvillus inclusion disease

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This is a rare, autosomal recessive cause of congenital diarrheal. Types: Early onset (95%): since birth Late onset (5%): 1-3 months Pathophysiology: Mutations MYO5B STXBP2 STX3 Disorder of apical vesicle traficking Dhekne HS, Pylypenko O, Overeem AW, Ferreira RJ, van der Velde KJ, Rings EHHM...

Pericentromeric satellite repeat expansions through RNA-derived DNA intermediates in cancer

Publication: Journal Article

Bersani, Francesca, Eunjung Lee, Peter Kharchenko, Andrew Xu, Mingzhu Liu, Kristina Xega, Olivia MacKenzie, et al. 2015. “Pericentromeric Satellite Repeat Expansions through RNA-Derived DNA Intermediates in Cancer”. Proc Natl Acad Sci U S A 112 (49): 15148-53.

Pathway level analysis by augmenting activities of transcription factor target genes

Publication: Journal Article

Jung, H., E. Lee, Kim, and D. Lee. 2009. “Pathway Level Analysis by Augmenting Activities of Transcription Factor Target Genes”. IET Syst Biol 3 (6): 534-42.

Comparative analysis of the JAK/STAT signaling through erythropoietin receptor and thrombopoietin receptor using a systems approach

Publication: Journal Article

Won, Hong-Hee, Inho Park, Eunjung Lee, Jong-Won Kim, and Doheon Lee. 2009. “Comparative Analysis of the JAK/STAT Signaling through Erythropoietin Receptor and Thrombopoietin Receptor Using a Systems Approach”. BMC Bioinformatics 10 Suppl 1: S53.

Softwares

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High Performance MBIR (parallel-beam) This is super fast code for parallel beam CT reconstruction on single node, multi-core CPUs. The main idea to achieve fast computations and convergence is super-voxels. Experiments show that super-voxels can accelerate MBIR CT reconstructions by more than 100...

Positions

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We are looking for passonate new talent with strong background in computational biology, mathematics, and/or scalable computing. If you are interested in joining our team to fulfill our vision together, please send your CV and a brief statement of your research interests to ealice.lee@childrens...

Rebeca Borges Monroy, PhD

Person: PhD Student, Bioinformatics and Integrative Genomics (BIG) (2017.1-2021.6), Current: Vertex Pharmaceuticals

Rebeca is currently a PhD student in the Bioinformatics and Integrative Genomics program at Harvard University, co-advised with Chris Walsh. She is interested in studying the genome in healthy brain development and how it is altered in disorders and diseases.

Junho Kim, PhD

Person: Postdoctoral Fellow (2017.4 - 2021.7), Current: Assistant Professor, Sungkyunkwan University, South Korea

Junho joined the lab in April, 2017. He received his Ph.D. in bioinformatics from KAIST in 2014 and did two years of postdoctoral training at Yonsei university college of medicine in South Korea. He has developed computational methods that detect low frequency somatic mutations (methods called...

Jaejoon (Jason) Choi, PhD

Person: Postdoctoral Fellow

Jason joined the lab in February, 2018 as a postdoctoral fellow. He received his Ph.D. in bioinformatics from KAIST in 2017. His PhD theisis focused on the analysis of network motifs in various real-world networks including moelcular interaction networks. During his training in bioinformatics for...

Specific Digestive Disorders

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Short bowel syndrome (short gut syndrome) Congenital intestinal pseudo-obstruction Microvillus inclusion disease Congenital tufting enteropathy Visceral hyperalgesia