Contributions to Science
1. My laboratory discovered the G protein-coupled receptor for sphingosine 1-phosphate (S1P) in the 1990s. At that time, S1P was widely considered as an intracellular second messenger. We cloned EDG-1 as an angiogenesis-inducible G protein-coupled receptor (GPCR) in 1990 and “de-orphaned” it as the...