Search

1. My laboratory discovered the G protein-coupled receptor for sphingosine 1-phosphate (S1P) in the 1990s. At that time, S1P was widely considered as an intracellular second messenger. We cloned EDG-1 as an angiogenesis-inducible G protein-coupled receptor (GPCR) in 1990 and “de-orphaned” it as the...

A BIG shoutout to Chao Li and Tim Dorweiler, AHA grant awardees ! Congrats and best wishes to Dairo (with Hla lab summer kids, Arlette and Emil)! Congratulations to Andrew Kuo on his publication! Kuo A, Hla T. Regulation of cellular and systemic sphingolipid homeostasis. Nat Rev Mol Cell Biol. 2024...

The recognition is that lymphocyte S1PR1 is essential for T and B lymphocyte recirculation and autoreactive adaptive immune cell trafficking has been firmly established with the launch of the first S1PR-targeted drug in 2010 for multiple sclerosis. However, given that S1P receptors play fundamental...

Here are some helpful links we use. Literature/Citation: https://icite.od.nih.gov/analysis https://scholar.google.com/ https://www.ncbi.nlm.nih.gov/pubmed Management of Mouse Colony: https://www.softmouse.net/ Screening Facility HMS: http://iccb.med.harvard.edu/rnai-screening Gene Ontology: https:/...