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A “CRISPR” view of Sturge-Weber syndrome is coming into focus November 6, 2017 Three-dimensional modeling and CRISPR-Cas9 gene editing technology are giving scientists a new view into Sturge-Weber syndrome , a rare congenital disorder that causes small blood vessels, called capillaries, to be...

Patients’ brain tissue unlocks the cellular hideout of Sturge-Weber’s gene mutation

News: March 01, 2017

A person born with a port-wine birthmark on his or her face and eyelid(s) has an 8 to 15 percent chance of being diagnosed with Sturge-Weber syndrome. The rare disorder causes malformations in certain regions of the body’s capillaries (small blood vessels). Port-wine birthmarks appear on areas of...

Couto, Javier, Lan Huang, Matthew Vivero, Nolan Kamitaki, Reid Maclellan, John Mulliken, Joyce Bischoff, Matthew Warman, and Arin Greene. 2016. “Endothelial Cells from Capillary Malformations Are Enriched for Somatic GNAQ Mutations”. Plast Reconstr Surg 137 (1): 77e-82e.

Treprostinil indirectly regulates endothelial colony forming cell angiogenic properties by increasing VEGF-A produced by mesenchymal stem cells

Publication: Journal Article

Smadja, David, Marilyne Levy, Lan Huang, Elisa Rossi, Adeline Blandinières, Dominique Israel-Biet, Pascale Gaussem, and Joyce Bischoff. 2015. “Treprostinil Indirectly Regulates Endothelial Colony Forming Cell Angiogenic Properties by Increasing VEGF-A Produced by Mesenchymal Stem Cells”. Thromb Haemost 114 (4): 735-47.

Valvular interstitial cells suppress calcification of valvular endothelial cells

Publication: Journal Article

Hjortnaes, Jesper, Kayle Shapero, Claudia Goettsch, Joshua Hutcheson, Joshua Keegan, Jolanda Kluin, John Mayer, Joyce Bischoff, and Elena Aikawa. 2015. “Valvular Interstitial Cells Suppress Calcification of Valvular Endothelial Cells”. Atherosclerosis 242 (1): 251-60.

Rapid onset of perfused blood vessels after implantation of ECFCs and MPCs in collagen, PuraMatrix and fibrin provisional matrices

Publication: Journal Article

Allen, Patrick, Kyu-Tae Kang, and Joyce Bischoff. 2015. “Rapid Onset of Perfused Blood Vessels After Implantation of ECFCs and MPCs in Collagen, PuraMatrix and Fibrin Provisional Matrices”. J Tissue Eng Regen Med 9 (5): 632-6.

Propranolol targets the contractility of infantile haemangioma-derived pericytes

Publication: Journal Article

Lee, D., Boscolo, Durham, Mulliken, Herman, and Bischoff. 2014. “Propranolol Targets the Contractility of Infantile Haemangioma-Derived Pericytes”. Br J Dermatol 171 (5): 1129-37.

Pericytes from infantile hemangioma display proangiogenic properties and dysregulated angiopoietin-1

Publication: Journal Article

Boscolo, Elisa, John Mulliken, and Joyce Bischoff. 2013. “Pericytes from Infantile Hemangioma Display Proangiogenic Properties and Dysregulated Angiopoietin-1”. Arterioscler Thromb Vasc Biol 33 (3): 501-9.