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Angiogenesis and lymphangiogenesis are regulated by vascular endothelial growth factor (VEGF) ligands and receptors under both physiological and pathological conditions. Endocytosis and intracellular transport of receptor complexes fine-tunes endothelial cell responses to VEGF, and these events are...

S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling

Publication: Journal Article

Geng, Xin, Keisuke Yanagida, Racheal Akwii, Dongwon Choi, Lijuan Chen, YenChun Ho, Boksik Cha, et al. 2020. “S1PR1 Regulates the Quiescence of Lymphatic Vessels by Inhibiting Laminar Shear Stress-Dependent VEGF-C Signaling”. JCI Insight 5 (14).

Enhanced hexose-6-phosphate dehydrogenase expression in adipose tissue may contribute to diet-induced visceral adiposity

Publication: Journal Article

Liu, Limei, Ying Wang, Jian Wang, Yunzhou Dong, Scarlett Chang, Xiwen Liu, Kabirullah Lutfy, et al. 2018. “Enhanced Hexose-6-Phosphate Dehydrogenase Expression in Adipose Tissue May Contribute to Diet-Induced Visceral Adiposity”. Int J Obes (Lond) 42 (12): 1999-2011.

Epsin deficiency promotes lymphangiogenesis through regulation of VEGFR3 degradation in diabetes

Publication: Journal Article

Wu, Hao, Ashiqur Rahman, Yunzhou Dong, Xiaolei Liu, Yang Lee, Aiyun Wen, Kim Ht To, et al. 2018. “Epsin Deficiency Promotes Lymphangiogenesis through Regulation of VEGFR3 Degradation in Diabetes”. J Clin Invest 128 (9): 4025-43.

Cardiotoxicity of Anticancer Therapeutics

Publication: Journal Article

Dong, Jerry, and Hong Chen. 2018. “Cardiotoxicity of Anticancer Therapeutics”. Front Cardiovasc Med 5: 9.

Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis

Publication: Journal Article

Xie, Daxing, Crystal Gore, Jun Liu, Rey-Chen Pong, Ralph Mason, Guiyang Hao, Michael Long, et al. 2010. “Role of DAB2IP in Modulating Epithelial-to-Mesenchymal Transition and Prostate Cancer Metastasis”. Proc Natl Acad Sci U S A 107 (6): 2485-90.

Epsins in vascular development, function and disease

Publication: Journal Article

Bhattacharjee, Sudarshan, Yang Lee, Bo Zhu, Hao Wu, Yabing Chen, and Hong Chen. 2021. “Epsins in Vascular Development, Function and Disease”. Cellular and Molecular Life Sciences 78 (3): 833-42.

About

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A graduate of Nankai University, Dr. Hong Chen completed her Ph.D. and postdoctoral training at the Yale University School of Medicine in the laboratory of Dr. Pietro De Camilli, where she discovered a family of endocytic adaptor proteins called epsins. Dr. Chen worked in the Cardiovascular Biology...

Therapeutic efficacy of a synthetic epsin mimetic peptide in glioma tumor model: uncovering multiple mechanisms beyond the VEGF-associated tumor angiogenesis

Publication: Journal Article

Dong, Jerry, Debra Saunders, Robert Silasi-Mansat, Lili Yu, Hua Zhu, Florea Lupu, Rheal Towner, Yunzhou Dong, and Hong Chen. 2018. “Therapeutic Efficacy of a Synthetic Epsin Mimetic Peptide in Glioma Tumor Model: Uncovering Multiple Mechanisms Beyond the VEGF-Associated Tumor Angiogenesis”. J Neurooncol 138 (1): 17-27.

Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development

Publication: Journal Article

Geng, Xin, Boksik Cha, Md Riaj Mahamud, Kim-Chew Lim, Robert Silasi-Mansat, Mohammad Uddin, Naoyuki Miura, et al. 2016. “Multiple Mouse Models of Primary Lymphedema Exhibit Distinct Defects in Lymphovenous Valve Development”. Dev Biol 409 (1): 218-33.