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Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread genotoxicity

Publication: Journal Article

Choudhury*, Sangita, August Yue Huang*, Kim, Zhou, Morillo, EA Maury, JW Tsai, et al. 2022. “Somatic Mutations in Single Human Cardiomyocytes Reveal Age-Associated DNA Damage and Widespread Genotoxicity”. Nature Aging 2 (8): 714-25.

Boxun awarded the ACMG Foundation/David L. Rimoin Inspiring Excellence Award

News: April 20, 2022

Boxun was awarded the ACMG Foundation/David L. Rimoin Inspiring Excellence Award at the 2022 ACMG Annual Clinical Genetics Meeting for his featured platform presentation, "Discovery and therapeutic implications of pathogenic retroelements in neurodegenerative diseases." Congratulations, Boxun! Read...

A neurodevelopmental disorder caused by a novel de novo SVA insertion in exon 13 of the SRCAP gene.

Publication: Journal Article

Zhao, Boxun, Jill A. Madden, Jasmine Lin, Gerard T. Berry, Monica H. Wojcik, Xuefang Zhao, Harrison Brand, Michael Talkowski, Eunjung Alice Lee**, and Pankaj B. Agrawal**. 2022. “A Neurodevelopmental Disorder Caused by a Novel de Novo SVA Insertion in Exon 13 of the SRCAP Gene.”. European Journal of Human Genetics 30 (9): 1083-87.

Persistent DNA damage associated with ATM kinase deficiency promotes microglial dysfunction

Publication: Journal Article

Bourseguin, Julie, Wen Cheng, Emily Talbot, Liana Hardy, Jenny Lai, Ailsa Jeffries, Michael Lodato, Eunjung Alice Lee, and Svetlana Khoronenkova. 2022. “Persistent DNA Damage Associated With ATM Kinase Deficiency Promotes Microglial Dysfunction”. Nucleic Acids Research 50 (5): 2700-2718.

Talk on transposon detection in ancient WGS data at Transposon Keystone meeting 2022

News: January 05, 2022

Elain's abstract on grnTea (pronounced green tea), a tool for transposon detection in ancient WGS data, was selected for a short talk at the transposon Keystone meeting. Congrats Elain!

Danielle joins the lab!

News: February 08, 2022

Danielle Denisko, a G2 in the Bioinformatics and Integrative Genomics (BIG) PhD program at Harvard, officially joined the lab. Welcome, Danielle!

Eduardo successfully defends his thesis. Congrats, Dr. Maury!

News: March 08, 2022

Eduardo successfully defended his PhD thesis, 'Somatic mutations in the human brain: Tracing the origins of cancer and schizophrenia'! Congrats Dr. Maury, we are so proud of you! Eduardo will be returning to medical school to complete his MD-PhD training at Harvard Medical School.

Hoang (Anh) Tran

Person: Bioinformatics Intern, Colby College, Current: PhD Student, UMass Chan Medical School

Hoang (Anh) Tran joined the Lee lab in August of 2021 as a bioinformatics intern while finishing up his double major in Computational Biology and Mathematics at Colby College. While working for the lab, he realized his interest in studying the roles of transposable elements in diseases, as well as...

Platform Presentation on pathogenic retroelements in neurodegenerative diseases

News: December 13, 2021

Boxun's abstract on "Discovery and therapeutic implications of pathogenic retroelements in neurodegenerative diseases" was selected as a Featured Platform Presentation at the 2022 ACMG Annual Clinical Genetics Meeting. Congrats, Boxun!

Justin Delano

Person: Rotation PhD Student, Bioinformatics and Integrative Genomics (BIG) (2022.2 - 2022.4)