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Jenny Lai successfully defended her thesis! Congrats Dr. Lai!

News: August 29, 2023

Jenny successfully defended her dissertation on " Functional genomic dissection of human brain development, degeneration, and dysfunction in pediatric neurogenetic disorders". She was an MD-PhD student in the Harvard/MIT MD-PhD Program in Neuroscience (PiN). Congratulations to Dr. Lai! We wish you...

Contribution and Therapeutic Implications of Retroelement Insertions in Ataxia Telangiectasia

Publication: Journal Article

Zhao, Boxun, Minh A Nguyen, Sijae Woo, Jinkuk Kim, Timothy W. Yu**, and Eunjung Alice Lee**. 2023. “Contribution and Therapeutic Implications of Retroelement Insertions in Ataxia Telangiectasia”. American Journal of Human Genetics 110 (11): 1976-82.

Boxun’s paper on transposon insertions causing Ataxia Telangiectasia, a rare disease in children got accepted at AJHG!

News: August 21, 2023

It is a first systematic study that reports the contribution of transposon insertions in a rare disease through a thorough WGS analysis and characterization of the insertional effects on RNA, especially on splicing. Furthermore it demonstrated a potential therapeutic intervention using ASOs for some...

Dushani Ranasinghe

Person: Research Fellow, Vascular Biology Program, Boston Children's Hospital, Research Fellow, Harvard Medical School

Dushani earned a Bachelor's degree in Biochemistry and Molecular Biology from the University of Colombo in Sri Lanka. She then enrolled in the University of Notre Dame to pursue a PhD in Biochemistry, conducting research under the guidance of Dr. Margaret Schwarz. Her doctoral project identified...

Jayoung and Mingyun join the lab as postdoctoral fellows!

News: August 30, 2023

We are excited to welcome two new postdoctoral fellows from Korea, Jayoung Ku and Mingyun Bae. Jayoung received a PhD in Chemical and Biomolecular Engineering from Korea Advanced Institute of Science and Technology (KAIST). Mingyun received his Ph.D. in computational biology from the same institute...

Somatic Ras/Raf/MAPK Variants Enriched in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy

Publication: Journal Article

Khoshkoo*, Sattar, Y. Wang*, Yasmine Chahine, Zeynep Erson-Omay, Stephanie Robert, Emre Kiziltug, Eyiyemisi C. Damisah, et al. 2023. “Somatic Ras/Raf/MAPK Variants Enriched in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy”. JAMA Neurology 80 (6): 578-87.

Our traditional lab retreat this year at Rolling Ridge, MA!

News: August 21, 2023

Last week, all our lab members had a great time relaxing and team building at Rolling Ridge Retreat Center in North Andover, MA from Aug 16 to 18. We had a variety of activities including scientific sessions, PI/tech talks, kayaking, hiking, playing escape room and board/video games! Huge thanks to...