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Lifetime Imaging Module Added to CFIC Core

News: January 07, 2025

Pleased to announce that the lifetime imaging module for 3 color channels is now available for use by any users. Please contact Michael Anderson at michael.anderson@childrens.harvard.edu if you are interested in it.

Mechanosensitive expression of lamellipodin promotes intracellular stiffness, cyclin expression and cell proliferation.

Publication: Journal Article

Brazzo, Joseph A, John C Biber, Erik Nimmer, Yuna Heo, Linxuan Ying, Ruogang Zhao, Kwonmoo Lee, Matthias Krause, and Yongho Bae. 2021. “Mechanosensitive Expression of Lamellipodin Promotes Intracellular Stiffness, Cyclin Expression and Cell Proliferation.”. Journal of Cell Science 134 (12).

Global Optimization of Clusters in Gene Expression Data of DNA Microarrays by Deterministic Annealing.

Publication: Journal Article

Lee, Kwonmoo, Tae Su Chung, and Ju Han Kim. 2003. “Global Optimization of Clusters in Gene Expression Data of DNA Microarrays by Deterministic Annealing.”. Genomics & Informatics 1 (1): 20-24.

Self-Assembly of Filopodia-Like Structures on Supported Lipid Bilayers

Publication: Journal Article

Lee, Kwonmoo, Jennifer L. Gallop, Komal Rambani, and Marc W. Kirschner. 2010. “Self-Assembly of Filopodia-Like Structures on Supported Lipid Bilayers”. Science 329 (5997): 1341-45.

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Hannah Wang

Person: Undergraduate Student

Hannah Wang is a third-year student at the Massachusetts Institute of Technology, majoring in Computation and Molecular Biology. She joined the Lee Lab in February 2025 and is currently working on using deep learning to analyze live cell movies and better understand breast cancer cells, with the...

Protocol to analyze deep-learning-predicted functional scores for noncoding de novo variants and their correlation with complex brain traits.

Publication: Journal Article

Mondragon-Estrada, Enrique, and Sarah U Morton. 2025. “Protocol to Analyze Deep-Learning-Predicted Functional Scores for Noncoding de Novo Variants and Their Correlation With Complex Brain Traits.”. STAR Protocols 6 (2): 103738.

Impact of congenital heart disease and prematurity on brain injury from a national registry.

Publication: Journal Article

Lima, Giulia P, Sarah U Morton, Isabella Zaniletti, Philip Levy, Nathaly Sweeney, Leeann Pavlek, Shannon E G Hamrick, et al. 2025. “Impact of Congenital Heart Disease and Prematurity on Brain Injury from a National Registry.”. Journal of Perinatology : Official Journal of the California Perinatal Association.

Genomic analysis of 11,555 probands identifies 60 dominant congenital heart disease genes.

Publication: Journal Article

Sierant, Michael C, Sheng Chih Jin, Kaya Bilguvar, Sarah U Morton, Weilai Dong, Wei Jiang, Ziyu Lu, et al. 2025. “Genomic Analysis of 11,555 Probands Identifies 60 Dominant Congenital Heart Disease Genes.”. Proceedings of the National Academy of Sciences of the United States of America 122 (13): e2420343122.