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Vascular malformations are defects in the architecture and function of arteries, veins, capillaries and lymphatic vessels. The malformations can be familial or sporadic, and are often associated with tissue overgrowth, deformity and infections. We focus on capillary malformations (CM) - excessive...

A “CRISPR” view of Sturge-Weber syndrome is coming into focus November 6, 2017 Three-dimensional modeling and CRISPR-Cas9 gene editing technology are giving scientists a new view into Sturge-Weber syndrome , a rare congenital disorder that causes small blood vessels, called capillaries, to be...

Years Name Position in Lab Current Position 2006-2014 Elisa Boscolo, PhD Post-doc/Instructor Assistant Professor, Cincinnati Children's Hospital, Cincinnati, OH 2013-2014 Matt Peacock Graduate Student Medical Student, Boston University, Boston, MA 2013-2014 Maria Gnarra, MD Graduate Student Post-doc...

Years Name Position in Lab Current Position 2018-2021 Zahra Alvandi Post-doc Biotech 2016-2020 Colette Bichsel Post-doc Scientist, Hoffman LaRoche, Basel, Switzerland 2018-2019 Jaakko Kangas Post-doc Physician 2018 Charlotte Erpicum Post-doc Biotech 2017- 2018 Stephen Dayneka Independent Study...

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Infantile hemangioma is a vascular tumor that can grow rapidly, causing organ damage, disfigurement and morbidity. My lab has focused on the cellular mechanisms that drive this uncontrolled vascular growth. We isolated increasingly less differentiated cells from hemangioma tissue (see figure), which...

Overview Our lab studies the role of endothelial cells and pericytes in vasculogenic and/or angiogenic diseases. We have three main areas: (1) vascular tumors (infantile hemangioma) and (2)vascular malformations (e.g., capillary malformation), (3) endothelial to mesenchymal transition (EndMT) in...

We study endothelial plasticity in cardiac valves and how this relates to the ability of valves to adapt to both normal and pathologic events. We showed that valve endothelial cells (VECs) from aortic, pulmonic and mitral valves can recapitulate processes that occur during valve development - e.g...

Joyce Bischoff, PhD Principle Investigator Joyce Bischoff received an A.B. in chemistry from Duke University and a Ph.D. in biochemistry from the Washington University School of Medicine. She was a post-doctoral fellow at the Whitehead Institute for Biomedical Research. She joined the Surgical...