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1. My laboratory discovered the G protein-coupled receptor for sphingosine 1-phosphate (S1P) in the 1990s. At that time, S1P was widely considered as an intracellular second messenger. We cloned EDG-1 as an angiogenesis-inducible G protein-coupled receptor (GPCR) in 1990 and “de-orphaned” it as the...

The recognition is that lymphocyte S1PR1 is essential for T and B lymphocyte recirculation and autoreactive adaptive immune cell trafficking has been firmly established with the launch of the first S1PR-targeted drug in 2010 for multiple sclerosis. However, given that S1P receptors play fundamental...

Here are some helpful links we use. Literature/Citation: https://icite.od.nih.gov/analysis https://scholar.google.com/ https://www.ncbi.nlm.nih.gov/pubmed Management of Mouse Colony: https://www.softmouse.net/ Screening Facility HMS: http://iccb.med.harvard.edu/rnai-screening Gene Ontology: https:/...

There are five high-affinity G protein-coupled receptors (GPCR) for S1P, termed as S1PR1-5. In the figure shown below, activation of S1PR1 by chaperone-bound S1P is schematically represented. Most cells express one or more subtypes of S1PRs. S1PR1 is abundantly expressed in the vascular endothelium...

While most cells produce S1P in the intracellular environment as a terminal product of sphingolipid metabolism, vertebrates secrete S1P into the extracellular environment by specific transporters (Proia RL, Hla T. Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy. J...

Researchers in the Hla lab develop protocols utilizing cutting edge technology combined with classical techniques and model systems to explore the fundamental biology of the vascular system and the diseases that affect it. Click title to open PDF:

2024 Kuo A, Hla T. Regulation of cellular and systemic sphingolipid homeostasis. Nat Rev Mol Cell Biol. 2024 Jun 18. Epub ahead of print. PMID: 38890457. Lin YC, Swendeman S, Moreira IS, Ghosh A, Kuo A, Rosário-Ferreira N, Guo S, Culbertson A, Levesque MV, Cartier A, Seno T, Schmaier A, Galvani S...