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The recognition is that lymphocyte S1PR1 is essential for T and B lymphocyte recirculation and autoreactive adaptive immune cell trafficking has been firmly established with the launch of the first S1PR-targeted drug in 2010 for multiple sclerosis. However, given that S1P receptors play fundamental...

Here are some helpful links we use. Literature/Citation: https://icite.od.nih.gov/analysis https://scholar.google.com/ https://www.ncbi.nlm.nih.gov/pubmed Management of Mouse Colony: https://www.softmouse.net/ Screening Facility HMS: http://iccb.med.harvard.edu/rnai-screening Gene Ontology: https:/...

Name (Instutition and duration with Dr. Hla) Current Appointment Past Postdoctoral Trainees Ari Ristimaki, M.D., Ph.D. GI Pathologist and Professor, Helsinki University, Finland Menq-Jer Lee, Ph.D. Retired Pazit Ben-Av, Ph.D. Research Scientist, Weizmann Institute, Israel Shobha Thangada, Ph.D...

There are five high-affinity G protein-coupled receptors (GPCR) for S1P, termed as S1PR1-5. In the figure shown below, activation of S1PR1 by chaperone-bound S1P is schematically represented. Most cells express one or more subtypes of S1PRs. S1PR1 is abundantly expressed in the vascular endothelium...

1. My laboratory discovered the G protein-coupled receptor for sphingosine 1-phosphate (S1P) in the 1990s. At that time, S1P was widely considered as an intracellular second messenger. We cloned EDG-1 as an angiogenesis-inducible G protein-coupled receptor (GPCR) in 1990 and “de-orphaned” it as the...

A BIG shoutout to Chao Li and Tim Dorweiler, AHA grant awardees ! Congrats and best wishes to Dairo (with Hla lab summer kids, Arlette and Emil)! Congratulations to Andrew Kuo on his publication! Kuo A, Hla T. Regulation of cellular and systemic sphingolipid homeostasis. Nat Rev Mol Cell Biol. 2024...