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Here are some helpful links we use. Literature/Citation: https://icite.od.nih.gov/analysis https://scholar.google.com/ https://www.ncbi.nlm.nih.gov/pubmed Management of Mouse Colony: https://www.softmouse.net/ Screening Facility HMS: http://iccb.med.harvard.edu/rnai-screening Gene Ontology: https:/...

Name (Instutition and duration with Dr. Hla) Current Appointment Past Postdoctoral Trainees Ari Ristimaki, M.D., Ph.D. GI Pathologist and Professor, Helsinki University, Finland Menq-Jer Lee, Ph.D. Retired Pazit Ben-Av, Ph.D. Research Scientist, Weizmann Institute, Israel Shobha Thangada, Ph.D...

There are five high-affinity G protein-coupled receptors (GPCR) for S1P, termed as S1PR1-5. In the figure shown below, activation of S1PR1 by chaperone-bound S1P is schematically represented. Most cells express one or more subtypes of S1PRs. S1PR1 is abundantly expressed in the vascular endothelium...

The Hla lab is investigating the biology of the lipid mediator sphingosine 1-phosphate (S1P). We are focused on the role of S1P signaling in embryonic development, normal physiology and disease processes relevant to cancer, vascular and immune systems.