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Angiogenesis and lymphangiogenesis are regulated by vascular endothelial growth factor (VEGF) ligands and receptors under both physiological and pathological conditions. Endocytosis and intracellular transport of receptor complexes fine-tunes endothelial cell responses to VEGF, and these events are...

A graduate of Nankai University, Dr. Hong Chen completed her Ph.D. and postdoctoral training at the Yale University School of Medicine in the laboratory of Dr. Pietro De Camilli, where she discovered a family of endocytic adaptor proteins called epsins. Dr. Chen worked in the Cardiovascular Biology...

We study a family of endocytic adaptor proteins called epsins, which are central to a number of important diseases in humans, including atherosclerosis, diabetes, cancer, and obesity. We have developed novel conditional mouse strains that have aided in the detailed characterization of epsins and...