Rationale for targeting the Wnt signalling modulator Dickkopf-1 for oncology.
Kagey, Michael H, and Xi He. 2017. “Rationale for Targeting the Wnt Signalling Modulator Dickkopf-1 for Oncology.”. British Journal of Pharmacology 174 (24): 4637-50.
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Notum is required for neural and head induction via Wnt deacylation, oxidation, and inactivation.
Zhang, Xinjun, Seong-Moon Cheong, Nathalia G Amado, Alice H Reis, Bryan T MacDonald, Matthias Zebisch, Yvonne Jones, Jose Garcia Abreu, and Xi He. 2015. “Notum Is Required for Neural and Head Induction via Wnt Deacylation, Oxidation, and Inactivation.”. Developmental Cell 32 (6): 719-30.
Disulfide bond requirements for active Wnt ligands.
MacDonald, Bryan T, Annie Hien, Xinjun Zhang, Oladoyin Iranloye, David M Virshup, Marian L Waterman, and Xi He. 2014. “Disulfide Bond Requirements for Active Wnt Ligands.”. The Journal of Biological Chemistry 289 (26): 18122-36.
FGF23-induced hypophosphatemia persists in Hyp mice deficient in the WNT coreceptor Lrp6.
Uchihashi, Kazuyoshi, Teruyo Nakatani, Regina Goetz, Moosa Mohammadi, Xi He, and Mohammed S Razzaque. 2013. “FGF23-Induced Hypophosphatemia Persists in Hyp Mice Deficient in the WNT Coreceptor Lrp6.”. Contributions to Nephrology 180: 124-37.
Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development.
Xu, Yufei, Chao Xu, Akiko Kato, Wolfram Tempel, Jose Garcia Abreu, Chuanbing Bian, Yeguang Hu, et al. 2012. “Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development.”. Cell 151 (6): 1200-13.
A finger on the pulse of Wnt receptor signaling.
MacDonald, Bryan T, and Xi He. 2012. “A Finger on the Pulse of Wnt Receptor Signaling.”. Cell Research 22 (10): 1410-2.
Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6.
MacDonald, Bryan T, Mikhail Semenov V, He Huang, and Xi He. 2011. “Dissecting Molecular Differences Between Wnt Coreceptors LRP5 and LRP6.”. PloS One 6 (8): e23537.
DKK1 antagonizes Wnt signaling without promotion of LRP6 internalization and degradation.
Semenov, Mikhail, V, Xinjun Zhang, and Xi He. 2008. “DKK1 Antagonizes Wnt Signaling Without Promotion of LRP6 Internalization and Degradation.”. The Journal of Biological Chemistry 283 (31): 21427-32.
A WNTer wonderland in Snowbird.
He, Xi, and Jeffrey D Axelrod. 2006. “A WNTer Wonderland in Snowbird.”. Development (Cambridge, England) 133 (14): 2597-603.
Threonine 41 in beta-catenin serves as a key phosphorylation relay residue in beta-catenin degradation.
Wu, Geng, and Xi He. 2006. “Threonine 41 in Beta-Catenin Serves As a Key Phosphorylation Relay Residue in Beta-Catenin Degradation.”. Biochemistry 45 (16): 5319-23.