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ATM-deficiency induced microglial activation promotes neurodegeneration in Ataxia-Telangiectasia

Publication: Journal Article

Lai, Jenny, Didem Demirbas, Junho Kim, Ailsa M. Jeffries, Allie Tolles, Junseok Park, Thomas W. Chittenden, et al. 2024. “ATM-Deficiency Induced Microglial Activation Promotes Neurodegeneration in Ataxia-Telangiectasia”. Cell Reports 43 (1).

Yayan Feng, PhD

Person: Postdoctoral Fellow

Yayan joined the lab in June 2024 as a postdoctoral fellow after a two-year postdoctoral training at Cleveland Clinic. She finished her PhD from Agricultural Genomics Institute at Shenzhen (AGIS), Chinese Academy of Agricultural Sciences (CAAS) in July 2021 with a major in biochemistry & molecular...

Shayna Mallett

Person:

Shayna is a computational research assistant in the Lee Lab. She graduated summa cum laude with her BS in Computer Science from Barrett the Honors College at Arizona State University in May 2022. She contributes to the pipeline development for identifying and analyzing somatic SNV and LINE-1 calling...

Human cytomegalovirus harnesses host L1 retrotransposon for efficient replication

Publication: Journal Article

Hwang*, Sung-Yeon, Hyewon Kim*, Danielle Denisko*, Boxun Zhao*, Dohoon Lee, Jiseok Jeong, Jinuk Kim, et al. 2024. “Human Cytomegalovirus Harnesses Host L1 Retrotransposon for Efficient Replication”. Nature Communications, Accepted.

Semin Lee, PhD

Person: Visiting Scholar, Associate Professor at Ulsan National Institute of Science and Technology (UNIST), South Korea

Semin is an Associate Professor in the Department of Biomedical Engineering at UNIST, South Korea. He joined the Lee lab in September 2024 as a visiting scholar. He received his BS in Biology from Seoul National University, MSc in BioSystems from Korea Advanced Institute of Science and Technology...

The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts

Publication: Journal Article

Saini, Natalie, Steven Roberts, Leszek Klimczak, Kin Chan, Sara Grimm, Shuangshuang Dai, David Fargo, et al. 2016. “The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts”. PLoS Genetics 12 (10): e1006385.

Somatic mutation in single human neurons tracks developmental and transcriptional history

Publication: Journal Article

Lodato, Michael, Mollie Woodworth, Semin Lee, Gilad Evrony, Bhaven Mehta, Amir Karger, Soohyun Lee, et al. 2015. “Somatic Mutation in Single Human Neurons Tracks Developmental and Transcriptional History”. Science 350 (6256): 94-98.

Primate genome architecture influences structural variation mechanisms and functional consequences

Publication: Journal Article

Gokcumen, Omer, Verena Tischler, Jelena Tica, Qihui Zhu, Rebecca Iskow, Eunjung Lee, Markus Hsi-Yang Fritz, et al. 2013. “Primate Genome Architecture Influences Structural Variation Mechanisms and Functional Consequences”. Proc Natl Acad Sci U S A 110 (39): 15764-9.

Copy number variation detection in whole-genome sequencing data using the Bayesian information criterion

Publication: Journal Article

Xi, Ruibin, Angela Hadjipanayis, L. J. Luquette, Tae-Min Kim, Eunjung Lee, Jianhua Zhang, Mark Johnson, et al. 2011. “Copy Number Variation Detection in Whole-Genome Sequencing Data Using the Bayesian Information Criterion”. Proc Natl Acad Sci U S A 108 (46): E1128-36.

Predicting disease phenotypes based on the molecular networks with condition-responsive correlation

Publication: Journal Article

Lee, Sejoon, Eunjung Lee, Kwang Hyuck Lee, and Doheon Lee. 2011. “Predicting Disease Phenotypes Based on the Molecular Networks With Condition-Responsive Correlation”. Int J Data Min Bioinform 5 (2): 131-42.