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Central venous access, assessment of tip placement & complications

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Placement Issues Clinical Vignette 1 Placement Issues Clinical Vignette 2 Central venous access procedure complications As HPN teams are often provide referrals for central line placement, it is important for team members to be familiar with the following common procedural complications: Arterial...

Metabolic Kidney Disease

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Nephrocalcinosis - Risk factors: prematurity, lasix exposure, nephrotoxins (antibiotics), calcium intake), vitamin D intake, fat malabsorption in colon (oxate stones), high vitamin D intake, family history of kidney stones - Diagnostic work-up: PTH, I cal, vitamin 1,25-OH D, urinalysis (blood, pH...

Quality Improvement

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Frankel A, Haraden C, Federico F, Lenoci-Edwards J. A Framework for Safe, Reliable, and Effective Care. White Paper. Cambridge, MA: Institute for Healthcare Improvement and Safe & Reliable Healthcare; 2017. http://www.ihi.org/resources/Pages/IHIWhitePapers/Framework-Safe-Reliab…...

The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts

Publication: Journal Article

Saini, Natalie, Steven Roberts, Leszek Klimczak, Kin Chan, Sara Grimm, Shuangshuang Dai, David Fargo, et al. 2016. “The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts”. PLoS Genetics 12 (10): e1006385.

Somatic mutation in single human neurons tracks developmental and transcriptional history

Publication: Journal Article

Lodato, Michael, Mollie Woodworth, Semin Lee, Gilad Evrony, Bhaven Mehta, Amir Karger, Soohyun Lee, et al. 2015. “Somatic Mutation in Single Human Neurons Tracks Developmental and Transcriptional History”. Science 350 (6256): 94-98.

Primate genome architecture influences structural variation mechanisms and functional consequences

Publication: Journal Article

Gokcumen, Omer, Verena Tischler, Jelena Tica, Qihui Zhu, Rebecca Iskow, Eunjung Lee, Markus Hsi-Yang Fritz, et al. 2013. “Primate Genome Architecture Influences Structural Variation Mechanisms and Functional Consequences”. Proc Natl Acad Sci U S A 110 (39): 15764-9.

Copy number variation detection in whole-genome sequencing data using the Bayesian information criterion

Publication: Journal Article

Xi, Ruibin, Angela Hadjipanayis, L. J. Luquette, Tae-Min Kim, Eunjung Lee, Jianhua Zhang, Mark Johnson, et al. 2011. “Copy Number Variation Detection in Whole-Genome Sequencing Data Using the Bayesian Information Criterion”. Proc Natl Acad Sci U S A 108 (46): E1128-36.

Predicting disease phenotypes based on the molecular networks with condition-responsive correlation

Publication: Journal Article

Lee, Sejoon, Eunjung Lee, Kwang Hyuck Lee, and Doheon Lee. 2011. “Predicting Disease Phenotypes Based on the Molecular Networks With Condition-Responsive Correlation”. Int J Data Min Bioinform 5 (2): 131-42.

Network-based classification of breast cancer metastasis

Publication: Journal Article

Chuang*, Han-Yu, Eunjung Alice Lee*, Yu-Tsueng Liu, Doheon Lee, and Trey Ideker. 2007. “Network-Based Classification of Breast Cancer Metastasis”. Mol Syst Biol 3: 140.

Research

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The Lee laboratory studies transposable elements and other types of genomic variations in human disease using computational genomic and bioinformatic approaches. Specifically, we develop and apply computational methods for genomic studies using next-generation sequencing and perform integrative...