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Quality Initiative Significantly Improves Outcomes for Children with Chronic Conditions

News: February 16, 2017

Cincinnati Children's Hospital Medical Center successfully improved outcomes for 50 percent of more than 27,000 pediatric patients, according to a new study published in the March 2017 issue of The Joint Commission Journal on Quality and Patient Safety." data-reactid="5" type="text">(OAK BROOK, IL...

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Andreane Cartier

Person: Staff Scientist, Vascular Biology Program, Boston Children's Hospital, Instructor, Harvard Medical School

Andreane did her PhD in the lab of Dr. Jean-Luc Parent in Sherbrooke, Quebec, where she studied the interaction between WDR36 and thromboxane A2 receptor (TPβ), and its impact on downstream signaling. Her training with Dr. Timothy Hla gives her the opportunity to apply her knowledge of GPCR...

Role of S1P Signaling in Physiology and Disease

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The recognition is that lymphocyte S1PR1 is essential for T and B lymphocyte recirculation and autoreactive adaptive immune cell trafficking has been firmly established with the launch of the first S1PR-targeted drug in 2010 for multiple sclerosis. However, given that S1P receptors play fundamental...

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Here are some helpful links we use. Literature/Citation: https://icite.od.nih.gov/analysis https://scholar.google.com/ https://www.ncbi.nlm.nih.gov/pubmed Management of Mouse Colony: https://www.softmouse.net/ Screening Facility HMS: http://iccb.med.harvard.edu/rnai-screening Gene Ontology: https:/...

Regulation and Function of S1P Receptors

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There are five high-affinity G protein-coupled receptors (GPCR) for S1P, termed as S1PR1-5. In the figure shown below, activation of S1PR1 by chaperone-bound S1P is schematically represented. Most cells express one or more subtypes of S1PRs. S1PR1 is abundantly expressed in the vascular endothelium...

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The Hla lab is investigating the biology of the lipid mediator sphingosine 1-phosphate (S1P). We are focused on the role of S1P signaling in embryonic development, normal physiology and disease processes relevant to cancer, vascular and immune systems.

Regulation and Function of S1P Gradients

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While most cells produce S1P in the intracellular environment as a terminal product of sphingolipid metabolism, vertebrates secrete S1P into the extracellular environment by specific transporters (Proia RL, Hla T. Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy. J...