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The Hla lab is investigating the biology of the lipid mediator sphingosine 1-phosphate (S1P). We are focused on the role of S1P signaling in embryonic development, normal physiology and disease processes relevant to cancer, vascular and immune systems.

While most cells produce S1P in the intracellular environment as a terminal product of sphingolipid metabolism, vertebrates secrete S1P into the extracellular environment by specific transporters (Proia RL, Hla T. Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy. J...

Researchers in the Hla lab develop protocols utilizing cutting edge technology combined with classical techniques and model systems to explore the fundamental biology of the vascular system and the diseases that affect it. Click title to open PDF:

Outpatient central line infection prevention bundle Encouraging good hand hygiene. Scrubbing the central line hub for 15 seconds before each line access. Changing central line dressing once per week or more frequently if soiled, using aseptic technique. Change the central line end cap using clean...

Deficiencies are prevalent in HPN patients, especially in light of product shortages and inevitable non-adherance. Providers vigalent surveillance & supplementation is worthwhile, as it has potential to impact outcomes. Falk A. Evaluating the effectiveness of a micronutrient assessment tool for long...

Causes of anemia Microcytic: Nutritional deficiencies- Iron, copper or zinc Anemia of chronic inflammation Hemaglobinopathy - thalassemias Sideroblastic anemias Normocytic: Acute GI bleeding Hemolytic - Hypersplenism, infection, trauma, G6PD, sickle cell, spherocytosis Chronic renal insufficiency...

Indications for HPN Hospitalization: - Fever 100.4 - Dehydration - Lack of working vascular access Failure with outpatient management (unable to provide HPN safely in community) Indications for liver failure hospitalization: - Acute altered mental status - Acute GI bleeding - Fever, concern for...