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Infusion Issues

PN cycling Infants at around 2 months-old can often tolerate cycling. Taper on by starting with one half the hourly rate for 30 to 60 minutes. Taper off by decreasing the hourly rate by one one for 30 to 60 minutes, then decrease the hourly rate by one fourth for 30 minutes.

Short bowel syndrome (short gut syndrome)

Short bowel syndrome (Definition): Condition resulting from Intestinal malabsorption related to massive surgical bowel resection -- ranges from mild intestinal dysfunction responsive dietary and pharmacological measures to severe intestinal failure requiring 100% parenteral support. Most important...

Publications

2024 Kuo A, Hla T. Regulation of cellular and systemic sphingolipid homeostasis. Nat Rev Mol Cell Biol. 2024 Jun 18. Epub ahead of print. PMID: 38890457. Lin YC, Swendeman S, Moreira IS, Ghosh A, Kuo A, Rosário-Ferreira N, Guo S, Culbertson A, Levesque MV, Cartier A, Seno T, Schmaier A, Galvani S...

Novel S1P Signaling-Based Therapeutics

We are exploring the hypothesis that biased agonists of the S1PRs will have unique signaling properties and therefore specific pharmacological properties. In addition, functional antagonists that target S1PRs to degradative pathways will likely lead to unique pharmacological properties and able to...

Pharmacy Reconcilliation

One in 10 hospitalized children are impacted by medication error. - As many as 35% of these errors are serious or life-threatening. - Less is known how common medical errors are in ambulatory patients where fewer preventive strategies are in place. Takata GS, Mason W, Taketomo C, Logsdon T, Sharek...