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The Lee laboratory studies transposable elements and other types of genomic variations in human disease using computational genomic and bioinformatic approaches. Specifically, we develop and apply computational methods for genomic studies using next-generation sequencing and perform integrative...

Cell lineage analysis in human brain using endogenous retroelements

Publication: Journal Article

Evrony*, Gilad, Eunjung Alice Lee*, Bhaven Mehta, Yuval Benjamini, Robert Johnson, Xuyu Cai, Lixing Yang, et al. 2015. “Cell Lineage Analysis in Human Brain Using Endogenous Retroelements”. Neuron 85 (1): 49-59.

Landscape of somatic retrotransposition in human cancers

Publication: Journal Article

Lee, Eunjung Alice, Rebecca Iskow, Lixing Yang, Omer Gokcumen, Psalm Haseley, L. J. Luquette, Jens Lohr, et al. 2012. “Landscape of Somatic Retrotransposition in Human Cancers”. Science 337 (6097): 967-71.

Prediction of extracellular matrix proteins based on distinctive sequence and domain characteristics

Publication: Journal Article

Jung, Juhyun, Taewoo Ryu, Yongdeuk Hwang, Eunjung Lee, and Doheon Lee. 2010. “Prediction of Extracellular Matrix Proteins Based on Distinctive Sequence and Domain Characteristics”. J Comput Biol 17 (1): 97-105.

Analysis of AML genes in dysregulated molecular networks

Publication: Journal Article

Lee, Eunjung, Hyunchul Jung, Predrag Radivojac, Jong-Won Kim, and Doheon Lee. 2009. “Analysis of AML Genes in Dysregulated Molecular Networks”. BMC Bioinformatics 10 Suppl 9: S2.

Inferring pathway activity toward precise disease classification

Publication: Journal Article

Lee*, Eunjung Alice, Han-Yu Chuang*, Jong-Won Kim, Trey Ideker**, and Doheon Lee**. 2008. “Inferring Pathway Activity Toward Precise Disease Classification”. PLoS Comput Biol 4 (11): e1000217.

Contact

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E. Alice Lee, Ph.D. phone 617-919-1589 | fax 617-919-2923 email ealice.lee at childrens.harvard.edu 3 Blackfan Circle, Boston, MA 02115 CLS (Center for Life Science) Building 15th Floor Office 15020 | Lab 15072 Find us on Google Maps

Kyu Park

Person: Junior Bioinformatician (2017.05 -2018.05), Current: Support Specialist, SOPHiA GENETICS

Kyu joined the lab as a Junior Bioinformatician in 2017 after studying computer science at Wentworth Institute of Technology. He revised, optimized, and ran the Tea (Transposable Element Analyzer) pipelines for various genomic projects in the lab. He came on board with little knowledge on biology...

NGSCheckMate: software for validating sample identity in next-generation sequencing studies within and across data types

Publication: Journal Article

Lee*, Sejoon, Soohyun Lee*, Woong-Yang Park, Eunjung Alice Lee**, and Peter J. Park**. 2017. “NGSCheckMate: Software for Validating Sample Identity in Next-Generation Sequencing Studies Within and across Data Types”. Nucleic Acids Research 45 (11): e103.

Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells

Publication: Journal Article

Yu, Vionnie, Rushdia Yusuf, Toshihiko Oki, Juwell Wu, Borja Saez, Xin Wang, Colleen Cook, et al. 2016. “Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells”. Cell 167 (5): 1310-1322.e17.