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Insights from Genetic Model Systems of Retinal Degeneration: Role of Epsins in Retinal Angiogenesis and VEGFR2 Signaling

Publication: Journal Article

Dong, Yunzhou, Xue Cai, Yong Wu, Yanjun Liu, Lin Deng, and Hong Chen. 2017. “Insights from Genetic Model Systems of Retinal Degeneration: Role of Epsins in Retinal Angiogenesis and VEGFR2 Signaling”. J Nat Sci 3 (1).

Role of endoplasmic reticulum stress signalling in diabetic endothelial dysfunction and atherosclerosis

Publication: Journal Article

Dong, Yunzhou, Conrad Fernandes, Yanjun Liu, Yong Wu, Hao Wu, Megan Brophy, Lin Deng, et al. 2017. “Role of Endoplasmic Reticulum Stress Signalling in Diabetic Endothelial Dysfunction and Atherosclerosis”. Diab Vasc Dis Res 14 (1): 14-23.

Genetic reduction of vascular endothelial growth factor receptor 2 rescues aberrant angiogenesis caused by epsin deficiency

Publication: Journal Article

Tessneer, Kandice, Satish Pasula, Xiaofeng Cai, Yunzhou Dong, John McManus, Xiaolei Liu, Lili Yu, et al. 2014. “Genetic Reduction of Vascular Endothelial Growth Factor Receptor 2 Rescues Aberrant Angiogenesis Caused by Epsin Deficiency”. Arterioscler Thromb Vasc Biol 34 (2): 331-37.

Endocytic adaptor protein epsin is elevated in prostate cancer and required for cancer progression

Publication: Journal Article

Tessneer, Kandice, Satish Pasula, Xiaofeng Cai, Yunzhou Dong, Xiaolei Liu, Lili Yu, Scott Hahn, et al. 2013. “Endocytic Adaptor Protein Epsin Is Elevated in Prostate Cancer and Required for Cancer Progression”. ISRN Oncol 2013: 420597.

Selective high-level expression of epsin 3 in gastric parietal cells, where it is localized at endocytic sites of apical canaliculi

Publication: Journal Article

Ko, Genevieve, Summer Paradise, Hong Chen, Morven Graham, Manuela Vecchi, Fabrizio Bianchi, Ottavio Cremona, Pier Paolo Di Fiore, and Pietro De Camilli. 2010. “Selective High-Level Expression of Epsin 3 in Gastric Parietal Cells, Where It Is Localized at Endocytic Sites of Apical Canaliculi”. Proc Natl Acad Sci U S A 107 (50): 21511-6.

About

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We study a family of endocytic adaptor proteins called epsins, which are central to a number of important diseases in humans, including atherosclerosis, diabetes, cancer, and obesity. We have developed novel conditional mouse strains that have aided in the detailed characterization of epsins and...

Gyorgy Baffy

Person: Associate Professor, Department of Medicine, Chief, Gastroenterology, VA Boston Healthcare System

Dr. Gyorgy Baffy is an Associate Professor of Medicine at Harvard Medical School and Chief of Gastroenterology at the VA Boston Healthcare System. He received his PhD from his studies conducted on growth factor-mediated calcium signaling in hepatocytes as an NIH Fogarty Fellow at the University of...

Longwood Nutrition Seminar

Events: Tuesday, Nov 02, 2021, 08:00am -Tuesday, Nov 02, 2021, 09:00am

“The Carbohydrate-Insulin Model: A Physiological Perspective on the Obesity Pandemic” David S. Ludwig, MD, PhDProfessor of Pediatrics, Harvard Medical SchoolProfessor of Nutrition, Harvard T.H. Chan School of Public HealthDivision of EndocrinologyCo-Director, New Balance foundation Obesity...

Longwood Seminar Series

Events: Tuesday, Mar 01, 2022, 07:00am -Tuesday, Mar 01, 2022, 08:00am

Dietary Guidelines for Americans 2020-2025 Ronald Kleinman, MD Massachusetts General Hospital for Children For zoom information, contact Coral Rudie or Barbara Ainsley

Editorial: The Role of the Lymphatic System in Lipid and Energy Metabolism, and Immune Homeostasis During Obesity and Diabetes

Publication: Journal Article

Cifarelli, Vincenza, Hong Chen, and Joshua Scallan. 2021. “Editorial: The Role of the Lymphatic System in Lipid and Energy Metabolism, and Immune Homeostasis During Obesity and Diabetes”. Frontiers in Physiology 12: 652461.