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伍斯特理工(WPI)机械与材料工程学院杨加伟课题组诚招全奖博士生以及博后
伍斯特理工学院 ( Worcester Polytechnic Institute )杨加伟课题组:软材料系统多尺度工程实验室( Multiscale Engineering of Soft Material Systems )计划于2024年1月1日成立。 软材料是一类高分子聚合物,相比于其他材料,其具备与人体组织高度匹配的性质,包括结构,机械,与生理等,是医疗应用中的理想材料。软材料制成的生物材料、医疗器件、医疗机器人等可以与人体组成一个紧密联系、相互作用的软材料系统,而对该系统的精确设计可以从根本上开发全新的医疗方法与手段来提高医疗水平、治疗疾病、甚至能进一步提升人类的潜力...
High Bone Mass-Causing Mutant LRP5 Receptors Are Resistant to Endogenous Inhibitors In Vivo.
Niziolek, Paul J, Bryan T MacDonald, Rajendra Kedlaya, Minjie Zhang, Teresita Bellido, Xi He, Matthew L Warman, and Alexander G Robling. 2015. “High Bone Mass-Causing Mutant LRP5 Receptors Are Resistant to Endogenous Inhibitors In Vivo.”. Journal of Bone and Mineral Research : The Official Journal of the American Society for Bone and Mineral Research 30 (10): 1822-30.
Wnt stabilization of β-catenin reveals principles for morphogen receptor-scaffold assemblies.
Kim, Sung-Eun, He Huang, Ming Zhao, Xinjun Zhang, Aili Zhang, Mikhail Semonov V, Bryan T MacDonald, et al. 2013. “Wnt Stabilization of β-Catenin Reveals Principles for Morphogen Receptor-Scaffold Assemblies.”. Science (New York, N.Y.) 340 (6134): 867-70.
Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development.
Xu, Yufei, Chao Xu, Akiko Kato, Wolfram Tempel, Jose Garcia Abreu, Chuanbing Bian, Yeguang Hu, et al. 2012. “Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development.”. Cell 151 (6): 1200-13.
Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation.
Zhang, Xinjun, Jose Garcia Abreu, Chika Yokota, Bryan T MacDonald, Sasha Singh, Karla Loureiro Almeida Coburn, Seong-Moon Cheong, et al. 2012. “Tiki1 Is Required for Head Formation via Wnt Cleavage-Oxidation and Inactivation.”. Cell 149 (7): 1565-77.
A finger on the pulse of Wnt receptor signaling.
MacDonald, Bryan T, and Xi He. 2012. “A Finger on the Pulse of Wnt Receptor Signaling.”. Cell Research 22 (10): 1410-2.
Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6.
Wu, Geng, He Huang, Jose Garcia Abreu, and Xi He. 2009. “Inhibition of GSK3 Phosphorylation of Beta-Catenin via Phosphorylated PPPSPXS Motifs of Wnt Coreceptor LRP6.”. PloS One 4 (3): e4926.
PAF makes it EZ(H2) for β-catenin transactivation.
Zhang, Xinjun, and Xi He. 2013. “PAF Makes It EZ(H2) for β-Catenin Transactivation.”. Molecular Cell 52 (2): 157-8.
Wnt stabilization of β-catenin reveals principles for morphogen receptor-scaffold assemblies.
Kim, Sung-Eun, He Huang, Ming Zhao, Xinjun Zhang, Aili Zhang, Mikhail Semonov V, Bryan T MacDonald, et al. 2013. “Wnt Stabilization of β-Catenin Reveals Principles for Morphogen Receptor-Scaffold Assemblies.”. Science (New York, N.Y.) 340 (6134): 867-70.