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Our lab's mission is to understand the organizational principles that underlie information processing in neural circuits. Our work is guided by several key questions: What rules underly network connectivity? What network motifs are conserved and what differentiates brains - and brain regions? What...

Publicly accessible electron microscopy datasets These datasets are made available under the Open Database License ( http://opendatacommons.org/licenses/odbl/1.0/). Any rights in individual contents of the database are licensed under the Database Contents License ( http://opendatacommons.org...

The Hla lab is investigating the biology of the lipid mediator sphingosine 1-phosphate (S1P). We are focused on the role of S1P signaling in embryonic development, normal physiology and disease processes relevant to cancer, vascular and immune systems.

While most cells produce S1P in the intracellular environment as a terminal product of sphingolipid metabolism, vertebrates secrete S1P into the extracellular environment by specific transporters (Proia RL, Hla T. Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy. J...

Researchers in the Hla lab develop protocols utilizing cutting edge technology combined with classical techniques and model systems to explore the fundamental biology of the vascular system and the diseases that affect it. Click title to open PDF: