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Human pulmonary valve progenitor cells exhibit endothelial/mesenchymal plasticity in response to vascular endothelial growth factor-A and transforming growth factor-beta2

Paruchuri, Sailaja, Jeong-Hee Yang, Elena Aikawa, Juan Melero-Martin, Zia Khan, Stavros Loukogeorgakis, Frederick J. Schoen, and Joyce Bischoff. 2006. “Human Pulmonary Valve Progenitor Cells Exhibit Endothelial/Mesenchymal Plasticity in Response to Vascular Endothelial Growth Factor-A and Transforming Growth Factor-Beta2”. Circ Res 99 (8): 861-9.

Hemangioma

Infantile hemangioma is a vascular tumor that can grow rapidly, causing organ damage, disfigurement and morbidity. My lab has focused on the cellular mechanisms that drive this uncontrolled vascular growth. We isolated increasingly less differentiated cells from hemangioma tissue (see figure), which...

Research

Overview Our lab studies the role of endothelial cells and pericytes in vasculogenic and/or angiogenic diseases. We have three main areas: (1) vascular tumors (infantile hemangioma) and (2)vascular malformations (e.g., capillary malformation), (3) endothelial to mesenchymal transition (EndMT) in...