Despite the development of potent drugs for modifiable risk factors, such as statins, and advances in mechanistic biomedical research, vascular disease remains the No.1 killer globally and represents a huge cost to public health. The underlying mechanisms remain incompletely understood and effective new therapies are needed. Such major challenges have promoted technological innovations and their implementations in vascular research. Unmet clinical needs and exponential technological development have synergistically advanced vascular medicine. Addressing the challenges associated with the complexity in treating cardiovascular disease requires integration of cross-disciplinary approaches and knowledge. This Research Topic thus reports new trends in a wide range of vascular medicine research from fundamental basic science to translational medicine to clinical studies.