Paper Publication in Epilepsia

We are thrilled to share that our paper, “Targeting Interictal Low-Entropy Zones during Epilepsy Surgery Predicts Successful Outcomes in Pediatric Drug-Resistant Epilepsy”, has just been published in Epilepsia.

In this work, we validated a new computational tool to map low-entropy brain activity using intracranial EEG in children with drug-resistant epilepsy.

What we found:
In a cohort of 75 children, we show that:
- Targeting low-entropy zones predicts surgical success more accurately than traditional paroxysmal EEG markers (spikes-on-ripple, fast-ripples)
- Entropy mapping is reproducible, even with brief interictal EEG epochs (unlike paroxysmal biomarkers).

To foster translation, we shared our entropy mapping code openly in Github, which can be run within the Brainstorm software, so researchers and clinicians can apply and build upon this method.

Kudos to the first author Navaneethakrishna Makaram and all the co-authors for making this work possible!