Berman R, Lee J, Olson K, Goldman M. Effects of naloxone on ethanol dependence in rats. Drug and Alcohol DependenceDrug and Alcohol Dependence. 1984;13:245–254.
NOTES
Accession Number: 1985-13874-001. First Author & Affiliation: Berman, Robert F.; Wayne State U. Release Date: 19850601. Publication Type: Journal, (0100); Peer Reviewed Journal, (0110); . Media Covered: Print. Media Available: Electronic; Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Dependency; Ethanol; Naloxone. Minor Descriptor: Drug Withdrawal; Rats. Classification: Psychopharmacology (2580) . Population: Animal (20); . Issue Publication Date: May, 1984
Abstract
Maintained 30 adult male Long-Evans rats on an ethanol-containing liquid diet. During development of ethanol dependence, the Ss were given ip injections of either naloxone (2 mg/kg) or saline daily. At the beginning of ethanol withdrawal, the Ss were injected with either naloxone (10 mg/kg) or saline ip. Ss injected with naloxone during the development of ethanol dependence consumed significantly more of the ethanol diet and therefore more ethanol than Ss injected with saline. Ss treated with naloxone throughout both the development of ethanol dependence and during ethanol withdrawal showed delayed or reduced withdrawal symptomatology compared to Ss injected with only saline, naloxone only during the development of dependence, or naloxone only during ethanol withdrawal. These results indicate that naloxone can alter the effects of chronic ethanol exposure and further suggest that ethanol may exert some of its actions through the brain opioid system. (36 ref) (PsycINFO Database Record (c) 2009 APA, all rights reserved)
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