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Lee Lab

We are a genomics research group at Boston Children’s Hospital and Harvard Medical School. We combine computational and experimental approaches to investigate transposable elements and somatic mutations, uncovering their mechanisms and contributions to human disease.

Welcome!

Our group studies how transposable elements and somatic mutations drive genome variation and human disease. Building on foundational discoveries in retrotransposition and somatic mosaicism enabled by single-cell and integrative genomics, we combine computational and experimental approaches to uncover mechanisms, such as RNA splicing alteration, and translate these insights into new diagnostic and therapeutic strategies.

Join the Lab!

We are looking for passionate and motivated scientists with strong backgrounds in computational biology, AI, mathematics, and/or scalable computing. Details can be found here. If you are interested in joining our team and contributing to our research, please send your CV and a brief statement of your research interests to ealice.lee@childrens.harvard.edu with “[Application]” in the subject line.

Our Latest Updates

  • Congratulations Dr. Denisko!

    Danielle Denisko passed her thesis defense on Non-canonical roles of transposable elements in human evolution and disease with flying colors! She was a PhD student in the Bioinformatics and...

  • Congratulations on the publication of Lan's paper!

    After much hard work, our lab's paper about somatic mutational burdens in chronic traumatic encephalopathy (CTE), has been published in Science! Congratulations to Lan, Shulin, Junho, August, and...