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Lifespan Big-Data MRI

Background: Big data is reshaping many aspects of healthcare. Brain MRI studies with over 1000 participants are often considered releative big sample size. Recent Nature, Science, PNAS and other studies used 10,000 or more publicly-shared brain MRIs, or 20,000-50,000 brain MRIs if combining public...

Brain Atlases

Background. A brain MRI atlases is a virtual brain image that is computed/constructed to represent the average anatomy and the average image intensity of all individuals in a cohort. Atlases are fundamental tools in computational neuroscience -- they are targets for image registration, guidlines for...

Image Segmentation

Background Field of View Normalization Skull Stripping (Brain Extraction) Structure Segmentation

Rare Disease (SWS)

Background: Pre-symptomatic Screening: Natural History: Outcome Prediction References:

Abnormality Detection

Background: Deep learning has been widely used to detect lesions in brain MRIs. However, a major challenge is the systematic low accuracy of deep learning in detecting small diffuse lesions, where the Dice overlap between expert- and computer-detected lesion regions is typically 0.3-0.7, compared to...

Interns/Co-ops (2021)

6-Month Interns/Co-ops in Machine Learning and Image Analysis (BS, MS, PhD, Postdoc levels), 2021-2022 Only 1 out of the 4 positions is open, with the starting date by the end o 2021 or early 2022. Open Positions: Four full-time research intern/co-op positions are open at the Image, Informatics, and...

Postdoc Opening (2020)

Research Fellow in Medical Image Analysis and Machine Learning This position has been filled. Thanks for your interest. Departments of Pediatrics and Radiology at Boston Children’s Hospital and Harvard Medical School invite applicants for the open positions at the postdoctoral research fellow and...

Brain Age Biomarker

Background: Machine learning can predict an individual's "brain age" from the brain MRI. Differences of ML-predicted and actual chronological ages show the accelearated or delayed aging, and can be associated with diseases, lifestyle, socioeconomics, genetic, and other environment influences...

Neonatal Brain Injury

1. Background 2. Abnormality Detection (Lesion Segmentation) 3. Neural Substrate 4. Outcome Prediction 5. References 1. Background. Neonatal brain injury caused by hypoxic ischemic encephalopathy (HIE) affects 1-5/1000 term-born infants. Therapeutic hypothermia (TH) reduces mortality/morbidity by...

Tumor Survivorship

Background Unique Clinical-trial Data Radiotherapy and Brain MRI Brain MRI and Neurocognitive Deficit Aging in Tumor Survivors References