Goldstein, Ann Y.N., and Thomas L. Schwarz. 2010. “Are Presynaptic Proteins Predisposed to Self-Assemble?”. Neuron 66 (5): 624-27.
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Abstract
Tight control of synapse formation ensures that neurons connect to appropriate targets. In this issue of Neuron, Klassen et al. identify ARL-8 GTPase as a regulator of presynaptic assembly. Without ARL-8, presynaptic material aggregates en route to its destination, suggesting that ARL-8 acts like a dispersant to prevent premature synaptic assembly in the axon.
Last updated on 11/27/2024