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Multi-platform framework for mapping somatic retrotransposition in human tissues

Publication: Journal Article

Wang, Seunghyun, Mingyun Bae, Jinhao Wang, Boxun Zhao, Khue Nguyen, Shayna Mallett, Jessica A. Switzenberg, et al. Submitted. “Multi-Platform Framework for Mapping Somatic Retrotransposition in Human Tissues”. BioRxiv, Submitted.

STRUMP-I: Structure-based machine learning approach to pMHC-I binding prediction using force field energy features

Publication: Journal Article

Voshall, Adam, Jeongjun Chae, Honglan Li, Junsu Ko, Woongyang Park, Eunjung Alice Lee, and Yoonjoo Choi. Submitted. “STRUMP-I: Structure-Based Machine Learning Approach to PMHC-I Binding Prediction Using Force Field Energy Features”. BioRxiv, Submitted.

Our Team

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We are a computational genomics and bioinformatics group in the Division of Genetics and Genomics at Boston Children's Hospital and Harvard Medical School. We are also affiliated with the Broad Institute of MIT and Harvard. Alice is a faculty member of the Harvard Bioinformatics and Integrative...

Rohini Gadde

Person:

Rohini is a computational research assistant who joined the Lee Lab in June 2025. She graduated from UC San Diego in 2023 with a BS in Bioinformatics and again in 2024 with an MS in Biology. She previously researched the impacts of transposable element insertions on DNA methylation and currently...

Inverted Alu repeats in loop-out exon skipping across hominoid evolution

Publication: Journal Article

Denisko, Danielle, Jeonghyeon Kim, Jayoung Ku, Boxun Zhao, and Eunjung Alice Lee. Forthcoming. “Inverted Alu Repeats in Loop-Out Exon Skipping across Hominoid Evolution”. Nucleic Acids Research, Forthcoming.

Recurrent patterns of widespread neuronal genomic damage shared by major neurodegenerative disorders

Publication: Journal Article

Zhou, Zinan, Lovelace J Luquette, Guanlan Dong, Junho Kim, Jayoung Ku, Kisong Kim, Mingyun Bae, et al. Forthcoming. “Recurrent Patterns of Widespread Neuronal Genomic Damage Shared by Major Neurodegenerative Disorders”. Cell, Forthcoming.

Diverse somatic genomic alterations in single neurons in chronic traumatic encephalopathy

Publication: Journal Article

Dong, Guanlan, Chanthia C. Ma, Shulin Mao, Samuel M. Naik, Katherine Sun-Mi Brown, Gannon A. McDonough, Junho Kim, et al. 2025. “Diverse Somatic Genomic Alterations in Single Neurons in Chronic Traumatic Encephalopathy”. Science.

Arnaz Maryam Tariq

Person:

Arnaz is a wet-lab research assistant originally from Bangladesh. She graduated from the University of Southern Mississippi in May 2025 with a BS in Biological Sciences (Microbiology) and a minor in Chemistry. Her honors thesis focused on the transcriptional analysis of inflammatory responses of...

Guanlan (Lan) Dong, PhD

Person: PhD Student, Bioinformatics and Integrative Genomics (BIG) (2019.09-2025.07)

Lan is a PhD student in the Bioinformatics and Integrative Genomics (BIG) program at Harvard University. She graduated from Washington University in St. Louis in 2019 with a degree in Mathematics and Computer Science. She is interested in studying the role of somatic mutations in aging and diseased...